Interleukin (IL)-35 is raising our expectations
نویسندگان
چکیده
منابع مشابه
Interleukin (IL)-35 is raising our expectations.
PURPOSE To elucidate and discuss the role of IL-35 in immunity to parasitic and bacterial infections as well as in autoimmunity in terms of its anti-inflammatory properties, we highlight significant findings on this novel member of the IL-12 family. METHODS Studies using genetically deficient mice have greatly enhanced our understanding of the biology of IL-35. On the basis of data derived fr...
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The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35. p35 is shared with the composite cytokine IL-35 which comprises of the p35/EBI3 heterodimer (EBI3 shared with IL-27). IL-35 signals via homo- or heterodimers of IL-12Rβ2, gp130 and WSX-1, which are shared with IL...
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ژورنال
عنوان ژورنال: Revista médica de Chile
سال: 2010
ISSN: 0034-9887
DOI: 10.4067/s0034-98872010000600015